Fig. 4
From: Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration
Cerebellum NeuN density decreases in C9orf72. a Representative images of NeuN IHC are shown for the granule cells of the cerebellum of FTLD-TDP cases due to the presence of a C9orf72 expansion and non-C9/GRN FTLD-TDP, as well as a normal brain from a cognitively intact subject. b Quantification of NeuN percent area in this region reveals a marked decrease in antigenicity in C9orf72 cases compared to non-C9/GRN (p < 0.05). A significant decrease was also observed with C9orf72 cases compared to control (p < 0.001). ANOVA (p = 0.0002) followed by Tukey’s HSD test are used to assess significance. Bar = 100 μL