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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Fig. 3

The effect of unlabeled EVs or WGA on 125I-EVs unidirectional influx following LPS. Both low (1 μg/mouse)- (a) and high (30 μg/mouse)- dose (b) of unlabeled EVs did not inhibit the increase of 125I-EVs uptake by brain in LPS treated mice. Values are means ± S.E.M. Kruskal-Wallis test ** p < 0.01 vs saline without unlabeled RBC-EVs n = 9-10/group. The effect WGA on the uptake by brain of 131I-EVs c WGA increased the uptake by brain of 131I-EVs in both saline and LPS treated mouse. Values are means ± S.E.M. One way ANOVA*** p < 0.001 vs saline without WGA or LPS without WGA, ### p < 0.001 vs saline with WGA, n = 5-6/group

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Acta Neuropathologica Communications

ISSN: 2051-5960

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