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Table 2 Summary of evidence supporting the exosomal transmission of pathogenic neurodegenerative disease proteins

From: Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?

  Size Sedimentation Sucrose gradient Marker Reference
Prion 50-90 nm 100,000 g O Flotillin, Tsg101 [16]
60-100 nm 100,000 g O Alix, Flotillin [35]
  Not described 110,000 g X Alix, Tsg101 [13]
Tau 60-100 nm 100,000 g O Alix [37]
  50-100 nm 100,000 g O Tsg101 [4]
  40-100 nm 100,000 g O Alix, Flotillin [44]
α-synuclein 50-140 nm 100,000 g X Alix, Flotillin [15]
  93, 99 nm 120,000 g X Alix, Flotillin, LAMP1 [3]
  60-100 nm 100,000 g X Alix, Flotillin, CD63 [10]
  ~100 nm 100,000 g X Flotillin [40]
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