Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?

Table 2 Summary of evidence supporting the exosomal transmission of pathogenic neurodegenerative disease proteins

	Size	Sedimentation	Sucrose gradient	Marker	Reference
Prion	50-90 nm	100,000 g	O	Flotillin, Tsg101	[16]
Aβ	60-100 nm	100,000 g	O	Alix, Flotillin	[35]
	Not described	110,000 g	X	Alix, Tsg101	[13]
Tau	60-100 nm	100,000 g	O	Alix	[37]
	50-100 nm	100,000 g	O	Tsg101	[4]
	40-100 nm	100,000 g	O	Alix, Flotillin	[44]
α-synuclein	50-140 nm	100,000 g	X	Alix, Flotillin	[15]
	93, 99 nm	120,000 g	X	Alix, Flotillin, LAMP1	[3]
	60-100 nm	100,000 g	X	Alix, Flotillin, CD63	[10]
	~100 nm	100,000 g	X	Flotillin	[40]

ISSN: 2051-5960