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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

Fig. 2

Proteomic analysis of exosome-enriched mouse brain EVs. A Venn diagram shows the overlap between biological replicates within each genotype for 2N (a) and Ts2 (b) EVs. c 1549 proteins were common to both genotypes. 91 and 18 proteins were unique to Ts2 and 2N samples, respectively. d GO analyses for components of the 1549 proteins common to both genotypes revealed enrichment of extracellular vesicles and exosomal proteins in the EVs preparations. P-values for each cellular category are shown on the right. e Representative Western-blots with anti-CD63 and anti-rab35 antibodies of the 2N and Ts2 sucrose gradient EVs fractions and corresponding quantification. Student t-test, n = 7 (*p < 0.05)

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