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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas

Fig. 5

a) In group 1 (ODG), we found that TERTp mutations were not associated with OS (P = 0.688). b) In patients with combined group 2 and 4 (total AAs), TERTp- mutant had poorer survival (p = 0.001) than TERTp-WT patients, due to TERTp mutation was more common in poor prognostic IDH-WT AA and older age over 55 years old. c) In patients with grade III IDH-WT AA, the TERTp-mutant group shows poorer OS compared to the TERTp-WT group but was not statistically significant due to shortage of the number of TERTp mutant case (p = 0.113), d) and has no effect on PFS (p = 0.527). e) In the Kaplan-Meier survival analysis, the TERTp-mutation status in patients with grade 4 IDH-WT has no effect on the patient’s OS (P = 0.393). f) A similar finding is seen in the IDH-mutant GBM groups (P = 0.370)

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