Skip to main content
Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Long-term neurologic and cardiac correction by intrathecal gene therapy in Pompe disease

Fig. 1

Experimental design and natural history of the disease in 6neo/6neo mice. a Overview of the experimental design. b Kinetic of apparition of the glycogen storage in Pompe mice. Paraffin-embedded sections, PAS-luxol (CNS) or PAS (heart, biceps femoris, and diaphragm) stain. Black arrowheads point to glycogen storage in glial cells, black arrows to storage in motor neurons, and red arrows to storage in cardiomyocytes. Glycogen (purple) is present from birth in the motor neurons of the brainstem, and from 2 weeks in the motor neurons of the spinal cord, in the glial cells of the cerebellum, and in the heart, and from 1 month for biceps femoris and diaphragm

Back to article page