Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G

Table 2 Blood chemistries before and 24 h after IP injection of AQP4-IgG in CD59^−/− and CD59^+/+ rats

Parameters	CD59^+/+ before	CD59^+/+ after	CD59^−/− before	CD59^−/− after	CD59^−/− +Comp_inh
ALP (U/L)	106 ± 77	63 ± 60	142 ± 93	117 ± 89	122 ± 21
AST (U/L)	60 ± 9	81 ± 23	129 ± 51	5784 ± 1021*	252 ± 34*
ALT (U/L)	36 ± 9	30 ± 9	50 ± 10	1182 ± 298*	60 ± 14
Creatine Kinase (U/L)	85 ± 9	120 ± 51	92 ± 9	106,767 ± 42901*	547 ± 84*
Albumin (g/dL)	2.9 ± 0.2	2.9 ± 0.3	2.9 ± 0.2	2.9 ± 0.3	2.8 ± 0.3
Total Bilirubin (mg/dL)	0.1 ± 0.1	0.1 ± 0.0	0.1 ± 0.0	0.2 ± 0.1	0.1 ± 0.0
Total Protein (g/dL)	5.8 ± 0.3	6.1 ± 0.3	5.8 ± 0.3	6.7 ± 0.6	5.6 ± 0.3
Globulin (g/dL)	2.9 ± 0.4	3.2 ± 0.4	2.9 ± 0.2	3.8 ± 0.1	2.8 ± 0.1
BUN (mg/dL)	13.6 ± 2.9	13.3 ± 3.3	14.7 ± 1.3	124 ± 46*	16.0 ± 4.4
Creatinine (mg/dL)	0.2 ± 0.0	0.3 ± 0.1	0.2 ± 0.1	1.2 ± 0.8*	0.3 ± 0.1
Cholesterol (mg/dL)	84 ± 20	83 ± 21	69 ± 11	110 ± 25	71 ± 10
Glucose (mg/dL)	208 ± 32	183 ± 14	198 ± 39	148 ± 82	205 ± 12
Calcium (mg/dL)	6.9 ± 4.4	5.1 ± 4.9	7.1 ± 4.2	6.2 ± 3.9	9.9 ± 0.2
Phosphorus (mg/dL)	5.3 ± 0.8	6.1 ± 1.1	6.0 ± 0.9	16.7 ± 6.1	6.9 ± 0.7
Bicarbonate (mmol/L)	20 ± 4	21 ± 2	21 ± 2	20 ± 4	22 ± 2
Chloride (mmol/L)	99 ± 4	98 ± 5	100 ± 3	90 ± 5	105 ± 3
Sodium (mmol/L)	136 ± 8	140 ± 2	138 ± 5	136 ± 6	143 ± 3

Mean ± S.E.M. of 4–6 rats per genotype (three males and three females)
ALP alkaline phosphatase, AST/ALT aspartate aminotransferase/alanine aminotransferase, CK creatine kinase, BUN blood urea nitrogen
*p < 0.01 comparing with untreated CD59^−/− rats