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Table 2 Blood chemistries before and 24 h after IP injection of AQP4-IgG in CD59−/− and CD59+/+ rats

From: Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G

Parameters CD59+/+
before
CD59+/+
after
CD59−/−
before
CD59−/−
after
CD59−/−
+Compinh
ALP (U/L) 106 ± 77 63 ± 60 142 ± 93 117 ± 89 122 ± 21
AST (U/L) 60 ± 9 81 ± 23 129 ± 51 5784 ± 1021* 252 ± 34*
ALT (U/L) 36 ± 9 30 ± 9 50 ± 10 1182 ± 298* 60 ± 14
Creatine Kinase (U/L) 85 ± 9 120 ± 51 92 ± 9 106,767 ± 42901* 547 ± 84*
Albumin (g/dL) 2.9 ± 0.2 2.9 ± 0.3 2.9 ± 0.2 2.9 ± 0.3 2.8 ± 0.3
Total Bilirubin (mg/dL) 0.1 ± 0.1 0.1 ± 0.0 0.1 ± 0.0 0.2 ± 0.1 0.1 ± 0.0
Total Protein (g/dL) 5.8 ± 0.3 6.1 ± 0.3 5.8 ± 0.3 6.7 ± 0.6 5.6 ± 0.3
Globulin (g/dL) 2.9 ± 0.4 3.2 ± 0.4 2.9 ± 0.2 3.8 ± 0.1 2.8 ± 0.1
BUN (mg/dL) 13.6 ± 2.9 13.3 ± 3.3 14.7 ± 1.3 124 ± 46* 16.0 ± 4.4
Creatinine (mg/dL) 0.2 ± 0.0 0.3 ± 0.1 0.2 ± 0.1 1.2 ± 0.8* 0.3 ± 0.1
Cholesterol (mg/dL) 84 ± 20 83 ± 21 69 ± 11 110 ± 25 71 ± 10
Glucose (mg/dL) 208 ± 32 183 ± 14 198 ± 39 148 ± 82 205 ± 12
Calcium (mg/dL) 6.9 ± 4.4 5.1 ± 4.9 7.1 ± 4.2 6.2 ± 3.9 9.9 ± 0.2
Phosphorus (mg/dL) 5.3 ± 0.8 6.1 ± 1.1 6.0 ± 0.9 16.7 ± 6.1 6.9 ± 0.7
Bicarbonate (mmol/L) 20 ± 4 21 ± 2 21 ± 2 20 ± 4 22 ± 2
Chloride (mmol/L) 99 ± 4 98 ± 5 100 ± 3 90 ± 5 105 ± 3
Sodium (mmol/L) 136 ± 8 140 ± 2 138 ± 5 136 ± 6 143 ± 3
  1. Mean ± S.E.M. of 4–6 rats per genotype (three males and three females)
  2. ALP alkaline phosphatase, AST/ALT aspartate aminotransferase/alanine aminotransferase, CK creatine kinase, BUN blood urea nitrogen
  3. *p < 0.01 comparing with untreated CD59−/− rats