Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G

Table 1 Hematological parameters before and 24 h after IP injection of AQP4-IgG in CD59^−/− and CD59^+/+ rats

	Hb (g/dl)	RBC (1012/L)	HCT (%)	RDW (%)	Retic (%)	WBC (109/L)	Plt (109/L)
Before AQP4-IgG administration
CD59^+/+	15.1 ± 2.0	9.2 ± 1.2	44.4 ± 6.0	13.5 ± 1.9	0.0 ± 0.0	7.5 ± 0.7	870 ± 162
CD59^−/−	13.9 ± 1.1	8.5 ± 0.9	41.5 ± 4.4	13.4 ± 1.0	0.4 ± 0.2⁺	8.1 ± 1.4	828 ± 114
24 h after AQP4-IgG administration
CD59^+/+	13.6 ± 1.1	8.8 ± 0.9	40.8 ± 3.0	13.3 ± 1.9	0.0 ± 0.0	6.8 ± 3.4	741 ± 207
CD59^−/−	18.4 ± 1.8*	11.4 ± 1.9*	55.7 ± 6.1*	13.6 ± 0.9	0.3 ± 0.1⁺	9.1 ± 5.6	685 ± 195
CD59^−/− + Comp_inh	13.4 ± 0.5	7.6 ± 0.2	40.0 ± 2.4	12.6 ± 0.7	0.3 ± 0.2⁺	5.2 ± 1.2	686 ± 99

Mean ± S.E.M. of 4–6 rats per genotype (three males and three females)
Hb hemoglobin, RBC red blood cell count, HCT hematocrit, RDW RBC distribution width; Retic reticulocyte count, WBC white blood cell count, Plts platelet count
*p < 0.01 comparing with AQP4-IgG-treated CD59^+/+ rats. ⁺ p < 0.01 comparing with untreated CD59^+/+ rats

ISSN: 2051-5960