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Table 1 Hematological parameters before and 24 h after IP injection of AQP4-IgG in CD59−/− and CD59+/+ rats

From: Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G

  Hb (g/dl) RBC (1012/L) HCT (%) RDW (%) Retic (%) WBC (109/L) Plt (109/L)
Before AQP4-IgG administration
 CD59+/+ 15.1 ± 2.0 9.2 ± 1.2 44.4 ± 6.0 13.5 ± 1.9 0.0 ± 0.0 7.5 ± 0.7 870 ± 162
 CD59−/− 13.9 ± 1.1 8.5 ± 0.9 41.5 ± 4.4 13.4 ± 1.0 0.4 ± 0.2+ 8.1 ± 1.4 828 ± 114
24 h after AQP4-IgG administration
 CD59+/+ 13.6 ± 1.1 8.8 ± 0.9 40.8 ± 3.0 13.3 ± 1.9 0.0 ± 0.0 6.8 ± 3.4 741 ± 207
 CD59−/− 18.4 ± 1.8* 11.4 ± 1.9* 55.7 ± 6.1* 13.6 ± 0.9 0.3 ± 0.1+ 9.1 ± 5.6 685 ± 195
 CD59−/− + Compinh 13.4 ± 0.5 7.6 ± 0.2 40.0 ± 2.4 12.6 ± 0.7 0.3 ± 0.2+ 5.2 ± 1.2 686 ± 99
  1. Mean ± S.E.M. of 4–6 rats per genotype (three males and three females)
  2. Hb hemoglobin, RBC red blood cell count, HCT hematocrit, RDW RBC distribution width; Retic reticulocyte count, WBC white blood cell count, Plts platelet count
  3. *p < 0.01 comparing with AQP4-IgG-treated CD59+/+ rats. + p < 0.01 comparing with untreated CD59+/+ rats