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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

Fig. 6

GABAergic neuron loss in OSK-KI mice. (a) Brain sections at 4 months were stained with anti-parvalbumin antibody. Photographs were taken from the dentate gyrus (DG) and entorhinal cortex (EC). Scale bar = 30 μm. Parvalbumin-positive GABAergic neurons in the granular cell layer (GCL) of the dentate gyrus within 1000 μm and in an area (700 × 600 μm) of the entorhinal cortex were counted. Each bar represents the mean ± SEM (n = 7 for each group). (b) Hippocampal homogenates at 4 months were subjected to Western blot with antibodies to GAD67/65 (GABA-synthetic enzyme), VGAT (GABA transporter), VGLUT1/2 (glutamate transporter), and actin. The signal densities were quantified. Each bar represents the mean ± SEM (n = 3 for each group)

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