Connectivity, not region-intrinsic properties, predicts regional vulnerability to progressive tau pathology in mouse models of disease

Table 1 This table presents all of the r-values and p-value thresholds reported in Figs. 2 & 3 and in the corresponding parts of the Results section

	Bolunda DSAD	Bolunda CBD	Iba Hipp. Inj.	Iba Str. Inj.	Clavaguera	Aggregate Meta-Dataset
Mouse Model	P301S	P301S	P301S	P301S	Alz17	/
Infusate	DSAD Homogenate	CBD Homogenate	Synthetic Tau Fibrils	Synthetic Tau Fibrils	P301S purified tau fibrils	/
Seed Region	CA1 & V1	CA1	CA1 & CA3	Caudoputamen	Hippocampus	Aggregate Meta-Seed
PROXIMITY (BIVARIATE CORRELATIONS)
Connectivity Proximity	0.34*	0.20	0.56***	0.37**	0.64**	0.35***
Spatial Proximity	0.05	−0.14	−0.02	−0.23*	0.17	−0.04
General Gene Proximity	−0.01	−0.10	−0.06	−0.38**	0.04	−0.12
Specific Tau Gene Proximity	0.05	0.29*	−0.08	−0.50***	0.05	−0.11
Noradrenergic Gene Proximity	−0.24*	−0.18	0.04	−0.28*	−0.18	−0.10
ABSOLUTE REGIONAL GENE EXPRESSION VS. CONNECTIVITY (MULTIVARIATE LINEAR MODEL)
Connectivity Proximity	0.35***	0.20	0.56***	0.38*	0.65**	0.35***
Summed Specific Tau Gene Ex.	−0.14	0.04	0.21	0.46**	−0.34*	0.21
Summed Noradrenergic Gene Ex.	0.28*	0.20	0.23	0.41*	0.56*	0.24*

The aggregated and per dataset r-values are all reported in this table. The r-values in each dark gray row separated section of the table were obtained independently from a standard Pearson Correlation to be compared with other proximity measurements (the top value) and from a Multivariate Linear Fit Model (the bottom value). Values above the dark row titled Lin. Mod. are using regional proximity to the seed region as the predictor of tau pathology severity, whereas values below that row compare connectivity proximity and regional gene expression, calculated using the Multivariate Linear Fit Model. *** p < 0.001, ** p < 0.01, * p < 0.05

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