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Table 1 This table presents all of the r-values and p-value thresholds reported in Figs. 2 & 3 and in the corresponding parts of the Results section

From: Connectivity, not region-intrinsic properties, predicts regional vulnerability to progressive tau pathology in mouse models of disease

  Bolunda DSAD Bolunda CBD Iba Hipp. Inj. Iba Str. Inj. Clavaguera Aggregate Meta-Dataset
Mouse Model P301S P301S P301S P301S Alz17 /
Infusate DSAD Homogenate CBD Homogenate Synthetic Tau Fibrils Synthetic Tau Fibrils P301S purified tau fibrils /
Seed Region CA1 & V1 CA1 CA1 & CA3 Caudoputamen Hippocampus Aggregate Meta-Seed
PROXIMITY (BIVARIATE CORRELATIONS)
 Connectivity Proximity 0.34* 0.20 0.56*** 0.37** 0.64** 0.35***
 Spatial Proximity 0.05 −0.14 −0.02 −0.23* 0.17 −0.04
 General Gene Proximity −0.01 −0.10 −0.06 −0.38** 0.04 −0.12
 Specific Tau Gene Proximity 0.05 0.29* −0.08 −0.50*** 0.05 −0.11
 Noradrenergic Gene Proximity −0.24* −0.18 0.04 −0.28* −0.18 −0.10
ABSOLUTE REGIONAL GENE EXPRESSION VS. CONNECTIVITY (MULTIVARIATE LINEAR MODEL)
 Connectivity Proximity 0.35*** 0.20 0.56*** 0.38* 0.65** 0.35***
 Summed Specific Tau Gene Ex. −0.14 0.04 0.21 0.46** −0.34* 0.21
 Summed Noradrenergic Gene Ex. 0.28* 0.20 0.23 0.41* 0.56* 0.24*
  1. The aggregated and per dataset r-values are all reported in this table. The r-values in each dark gray row separated section of the table were obtained independently from a standard Pearson Correlation to be compared with other proximity measurements (the top value) and from a Multivariate Linear Fit Model (the bottom value). Values above the dark row titled Lin. Mod. are using regional proximity to the seed region as the predictor of tau pathology severity, whereas values below that row compare connectivity proximity and regional gene expression, calculated using the Multivariate Linear Fit Model. *** p < 0.001, ** p < 0.01, * p < 0.05