Fig. 3

An example of ND modeling and associated analyses. a Here we demonstrate what is meant by representing the brain as a network, with each ball indicating the center of mass of a region and each line between any pair of regions implying the presence of a connection between them. b Here we demonstrate the parameter optimization or βt curve for ND modeling. A predictive curve, or one where the network used for ND modeling adds predictive value beyond a starting point has a defined peak at βt > 0, whereas a non-predictive model will show a peak at βt = 0. The delta-R measure indicated here refers to the increase in r-value from baseline given by ND. c Here we provide an anatomic illustration of the predictions over time given by ND modeling about regional pathology severity, with each ball representing a region, and the size of the ball indicating the degree of pathology severity