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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Connectivity, not region-intrinsic properties, predicts regional vulnerability to progressive tau pathology in mouse models of disease

Fig. 1

Connectivity proximity better correlates with regional pathology severity than gene expression profile proximity. Here proximity is demonstrated in terms of connectivity and gene expression profile, using the 10 regions most proximal to the CA1 seed region from [4]. The thickness of each pipe represents how proximal each region is with CA1, with thicker pipes indicating higher proximity, while each ball represents the regional tau pathology severity. a Connectivity proximity with CA1 corresponds better with regional tau proteinopathy severity than does (b) gene expression profile proximity with CA1. In an aggregated meta-dataset of all exogenously seeded mouse studies used in the present work, connectivity produced the best fit with empirical regional tau pathology data (b) and produced the best, only positive, and significantly strongest relationship, as measured by r-value and tested with Fisher’s R-to-Z Test, with regional tau pathology data (c). *** p < 0.001, in the Fisher’s R-to-Z Test for comparing r-values

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