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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Cryptic amyloidogenic elements in mutant NEFH causing Charcot-Marie-Tooth 2 trigger aggresome formation and neuronal death

Fig. 5

NEFH mutations trigger caspase 3 dependent death in vitro. a Confocal images of transfected SH-EP counterstained with DAPI in blue and activated caspase 3 in red. Scale bar: 20 μm. b Percentage of caspase 3 activated positive cells overtime. Values represent means +/− sem from at least three independent experiment analyzed by one way ANOVA followed by multiple comparisons versus control group (Dunnett’s Method) * p < 0.02; ** p < 0.001. c Quantification of the percentage of propidium iodide permeable cells. Values represent means +/− sem from at least three independent experiment analyzed by one way ANOVA followed by multiple comparisons versus control group (Dunnett’s Method) * p < 0.02

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Acta Neuropathologica Communications

ISSN: 2051-5960

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