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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Fig. 4

αSyn pathology is associated with astrogliosis but no changes in microglia profile. a, c Representative brain sections immunostained with anti-GFAP (a) and anti-iba1 (c) in hippocampus of 3 months old mice. b Detailed cell count and morphological analysis across time shows that the number of GFAP positive cells is significantly higher in AAV1-αsyn than AAV-venus, also astroglial cells present more processes and a larger body area. d The same morphological analysis was performed with the iba1 positive cells. At 1 months of age a higher number of microglia was observed but was not maintained at 3 or 6 months. No morphological microglia changes could be observed at 3 or 6 months of age. Scale bars in a, c = 200 μm, and i, ii, i’ and ii’ = 50 μm,* p < 0.001, AAV-αsyn vs AAV-venus

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