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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Fig. 2

Widespread expression of the transgene throughout the whole brain of adult mice. (a-l) Photomicrographs of representative regions of 3 month old brain of AAV1-αsyn injected mice. Intense cytoplasmic staining in the olfactory bulb (a, b), thalamic (c, d) and cortical regions (e, f) with some axonal projections (black arrows). Also strong neuropil burden was observed in several regions within the striatum (g, h), midbrain (k, l) and hippocampus (i, j). (m-r). Co-immunostaining for human αsyn and dopaminergic (TH) neuronal marker at the level of the SN (m, o, q) and Striatum (n, p, r). TH+ cell bodies and fibers expressed the transgene as observed in overlay pictures. Scale bar in A = 500 μm and apply to c, e, g, i, k; Scale bar in b = 50 μm and apply to d, f, h, j, l; Scale bar in m = 20 μm

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