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Table 3 Median values with interquartile range for hnRNP E2 immunostaining of pathological inclusions, neuronal nuclei and cytoplasm in frontal and temporal cortex, and dentate gyrus of hippocampus, for each pathological subgroup

From: Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration

  

Frontal cortex

 

Group

E2 inclusions

E2 nucleus

E2 cytoplasm

FTLD-TDP type A

0 (0-0)

1 (0-1)

1 (0-2)

FTLD-TDP type B

0 (0-0)

0.75 (0-1.25)

1 (0-1.25)

FTLD-TDP type C

1 (1-2)

1 (0-3)

1 (0.5-2)

FTLD-tau

0 (0-0)

2 (1-2)

1 (0-2)

Healthy Controls

0 (0-0)

1.5 (0-3)

1.5 (0-2.25)

 

Temporal cortex

E2 inclusions

E2 nucleus

E2 cytoplasm

FTLD-TDP type A

0 (0-0)

1 (0-1)

1 (0-2)

FTLD-TDP type B

0 (0-0)

0.75 (0-1.25)

1 (0-1.25)

FTLD-TDP type C

1 (1-3)

2 (0-3)

2 (0.5-3)

FTLD-tau

0 (0-0)

2 (1-2)

1 (0-2)

Healthy Controls

0 (0-0)

1.5 (0-3)

1.5 (0-2.25)

 

Dentate Gyrus

E2 inclusions

E2 nucleus

E2 cytoplasm

FTLD-TDP type A

0 (0-0)

1 (0-1)

1 (0-2)

FTLD-TDP type B

0 (0-0)

0.75 (0-2)

1 (0-2)

FTLD-TDP type C

2 (0-3)

2 (0-3)

2 (0-3)

FTLD-tau

0 (0-0)

1 (0-3)

1 (0-2)

Healthy Controls

0 (0-0)

1.5 (0-3)

1.5 (0-2.25)

 

TDP-43 inclusions

Frontal cortex

Temporal cortex

Dentate Gyrus

FTLD-TDP type A

3 (2-3)

3 (2-3)

1 (1-1.25)

FTLD-TDP type B

2 (2-3)

2 (2-3)

2 (1-3)

FTLD-TDP type C

2 (2-3)

3 (2-3)

3 (2-3)

FTLD-tau

0 (0-0)

0 (0-0)

0 (0-0)

Healthy Controls

0 (0-0)

0 (0-0)

0 (0-0)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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