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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice

Fig. 3

iP subunit deficiency has no impact on APP processing, on cerebral Aβ production and sAPPβ levels in brain homogenates in APPPS1 mice. a and (e) Representative image of Western blot analysis of APP, APPCTFβ and Aβ in brain homogenates of young 120 days old (a; upper panel) and aged 250 days old (e; lower panel) APPPS1;LMP7+/+ and respective littermate APPPS1;LMP7−/− mice (6E10 detection) and corresponding densitometric quantification (upper panel; b d , and lower panel; f h) (n = 4–6 mice per group, p > 0.05, Mann-Whitney test). i, Soluble APPbeta levels in Tris fractions of 49 day old pre-depositing APPPS1;LMP7+/+ and respective littermate APPPS1;LMP7−/− mice assessed by Human Swedish Soluble APPβ (sw sAPPβ) singleplex Meso Scale assay (Meso Scale Discovery) (n = 4 mice per group, p > 0.05, Mann-Whitney test)

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