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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Fig. 4

Demyelination in NHPs. Representative images of Olig001-α-syn or Olig001-GFP injected monkeys stained with Luxol Fast Blue. a Marked demyelination in the corpous callosum of Olig001-α-syn monkeys is shown by decreased Luxol Fast Blue staining (bottom left). The areas of demyelination correspond to phosphorylated Serine-129 α-syn immunoreactivity in level matched sections (top left). No loss of myelin was observed in Olig001-GFP injected monkeys (bottom right), indicating that demyelination was a result of α-syn overexpression and not a byproduct of the vector or GFP expression (top right). b In the striatum, regions of phosphorylated Serine-129 α-syn immunoreactivity (top left) associated with robust demyelination of internal capsule fibers and striasomes (bottom left), while GFP expression (top right) resulted in no changes in myelin (bottom right). Scale bar 500 μm

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