Fig. 2
From: Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
Altered cellular response in murine APP-deficient mice. Cortical brain sections were immunostained for Aβ and IBA1 (a, b, 150 d) or GFAP (c, d, 200 d) and contrasted using haematoxylin. Representative micrographs emphasize the impaired microglial response and pronounced astrogliosis in mAPP0/0 mice a, c compared to mAPP+/+ animals b, d. While the total area of microglial cells (IBA1+) was stable upon knockout of murine APP e, microglial coverage of plaques f and the total area of plaque associated microglial cells (G) were reduced. By contrast, a pronounced and age-dependent astrogliosis developed in mAPP0/0 mice (C, D, H). (Scale bars: 250 μm in overview, 50 μm in enlargements; * for p ≤ 0.05; n ≥ 7)