Fig. 1
From: Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
Deposition of β-amyloid is altered upon knockout of murine APP (mAPP0/0). Representative micrographs of cortical brain sections from 150 d old a mAPP0/0 and b mAPP+/+ mice, immunostained for hAβ and contrasted with haematoxylin illustrate the elevated deposition of human Aβ in murine APP-deficient mice. Semi-automatic analysis confirmed the increase in c amount of cortical plaques, d mean size of plaques and e plaque load (Aβ-positive cortical area). Immunoassays revealed f consistently higher levels of deposited (guanidine soluble) Aβ in mAPP0/0 mice, while g soluble (carbonate soluble) Aβ was only significantly changed at 125 d. In contrast to parenchyma, h deposition in leptomeningeal vessels was delayed in murine APP-deficient mice. (Scale bar: 500 μm; * p ≤ 0.05; n ≥ 7)