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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

Fig. 5

Inhibition of endocytosis inhibits exosomes-mediated α-syn accumulation. a Immunoblot and b electron microscopy confirm the presence of α-syn containing exosomes from DLB patient. Scale bar = 50 nm. c B103 neuronal cell lines incubated with either Ctl or DLB exosomes and were left alone (first row, Baseline), incubated in 4 °C (second row) or incubated with Dynasore (third row). Accumulation of α-syn was visualized using the Syn1 antibody. Detail column indicates the region of interest magnified. d Quantification of α-syn positive particles in 37 °C (baseline), incubation at 4 °C and at 37 °C with Dynasore. * = P < 0.05 (DLB compared to Ctl). Error bars indicate SEM

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