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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

Fig. 3

Administration of DLB exosomes into mouse brains initiates intracellular accumulation of phosphorylated proteins. a Representative EM micrographs of exosomes from Ctl and DLB brain samples immunolabeled for α-syn. b Schematic of stereotaxic injection into the hippocampus of C57BL/6 N × DBA/2 F1 mice. c Representative brightfield micrographs from mouse brains injected with control or DLB exosomes. Row 1: Sagittal view of the hippocampal area. Needle entry site is highlighted by arrowhead. Boxes highlight region of interest depicted in micrographs below. Scale bar = 150 μm. Rows 2–3: High magnification view of highlighted areas. Arrowheads highlight immunolabeled cell bodies. Scale bar = 25 μm. d Micrographs of brain tissue stained with phosphorylated α-syn (pSer129), PHF1 and Aβ (6E10). Scale bar = 25 μm. e Quantification of immunohistochemical stains from (c) and (d) through optical density. * = P < 0.05. Error bars indicate SEM

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