Fig. 4

Clinical characteristics of TCGA diffuse glioma clusters. a Survival curves from 2007 WHO histopathological classification criteria (A = diffuse astrocytoma, O = oligodendroglioma, OA = oligoastrocytoma, AA = anaplastic astrocytoma, AO = anaplastic oligodendroglioma, AOA = anaplastic oligoastrocytoma, GBM = glioblastoma). b Survival comparison of three main 2D molecular clusters. c-e Age at diagnosis distribution for each cluster. Patients with astrocytic glioma/glioblastoma are older at presentation in the (c) IDH-wildtype cluster than in the (d) IDH mutant cluster. e An apparent bimodal adult age distribution is seen in the oligodendroglioma cluster, with median age of 45 years. f Survival of patients with tumors of the oligodendroglioma cluster stratified by age (<45 versus ≥45 years) is significantly different (p = 0.0033), and comparable to survival stratified by WHO grade (g, h). P values determined using Cox proportional hazard regression