Fig. 3From: Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery2D visualization of the revised 2016 WHO classification of diffuse gliomas. Multidimensional scaling demonstrates three major clusters of diffuse gliomas. The 2007 WHO histopathologic classifiers are heterogeneous and non-specific with regards to the three main clusters. The 2016 WHO classification aligns well with the three major clusters and can be divided into: 1) oligodendroglial tumors, IDH-mutant and 1p/19q-codeleted (WHO grades II–III); 2) astrocytic gliomas/glioblastomas, IDH-mutant (WHO grades II–IV); and 3) astrocytic gliomas/glioblastomas, IDH-wildtype (WHO grades II–IV)Back to article page