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Table 1 Levels of phospholipids detected by 31P NMR in myelin purified from whole A53T α-Syn and control mouse brains

From: Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss

 

Control

A53T

α-Syn

P

PA

0.56 ± 0.16

0.90 ± 0.08

0.02*

PC

5.8 ± 1.4

10.5 ± 1.6

0.02*

PE

3.1 ± 1.0

4.9 ± 1.8

0.06

PI

0.4 ± 0.2

0.8 ± 0.2

0.02*

PS

2.6 ± 0.9

4.6 ± 0.5

0.05*

PE-plasm

6.6 ± 1.9

11.5 ± 3.3

0.03*

SPH

0.8 ± 0.3

1.7 ± 1.1

0.12

  1. Table 1 Calculated phosphorus signals for assigned phospholipids detected in lipid extracts of purified myelin from whole A53T α-Syn and control mice (in μmol per mg purified myelin, n = 5 mice). PA phosphatidic acid, PC phosphatidylcholine, PE phosphatidylethanolamine, PI phosphatidylinositol, PS phosphatidylserine, SPH sphingomyelin; and PE-plasm., phosphatidylethanolamine-plasmalogen; *P < 0.05, one-way ANOVA
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Acta Neuropathologica Communications

ISSN: 2051-5960

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