Fig. 3
From: Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene
Main histological lesions consisted in hypoplasia of the SCO (thick arrow) and colliculi, small aqueduct with rosettes in its inferior part (thin arrow) (a) compared with an age-matched control whose SCO has a normal size (arrow) (b) In foetus 4, the patent cerebral aqueduct possessed multiple indentations with rosettes in its dorsal and ventral parts [OM x 100] (c) At higher magnification the rosettes were most often lined by ciliated ependyma, and surrounded by small round-shaped cells (arrows) (d) and in foetus 4 atresia of the ependymal canal was observed at the level of the decussation of the pyramids (arrow) [OM x 20] (e) The immature cells were either dispersed or clustered (arrow) (f) and similar lesions observed around third ventricle (arrows) at the level of the interpeduncular fossa, between the red nuclei (asterisks) (g) as well as close to the 4th ventricle ependyma of the fourth ventricle (arrow) which was abnormal in shape (h)