Table 1 Selected clinical, neuropathological and genetic details on patients studied. FTLD = Frontotemporal Lobar degeneration; MND = Motor Neurone Disease
Group | M/F | Age at onset (y) | Age at death (y) | Duration of illness (y) |
|---|---|---|---|---|
FTLD-TDP type A (n = 25) | 14/11 | 61.0 ± 5.9 | 69.0 ± 5.1 | 8.0 ± 3.3 |
FTLD-TDP type B (n = 15) | 9/6 | 57.1 ± 7.4 | 62.3 ± 8.0 | 5.3 ± 4.5 |
FTLD-TDP type C (n = 10) | 6/4 | 59.9 ± 7.1 | 71.8 ± 5.7 | 11.9 ± 5.0 |
FTLD-tau (n = 11) | 4/7 | 51.4 ± 6.4 | 61.4 ± 5.4 | 10.0 ± 3.1 |
MND (n = 4) | 4/0 | 53.3 ± 7.3 | 56.3 ± 8.3 | 3.0 ± 1.4 |
FTLD/MND C9orf72 expansion (n = 21) | 13/8 | 57.3 ± 6.0 | 63.5 ± 6.4 | 6.2 ± 4.1 |
FTLD GRN mutation (n = 9) | 5/4 | 60.7 ± 5.6 | 69.3 ± 4.1 | 8.7 ± 3.9 |
FTLD No mutation (n = 24) | 15/9 | 60.2 ± 7.8 | 68.5 ± 8.9 | 8.4 ± 4.9 |
FTLD MAPT mutation (n = 11) | 4/7 | 51.4 ± 6.4 | 61.4 ± 5.4 | 10.0 ± 3.1 |
Healthy Controls (n = 10) | 3/7 | na | 83.3 ± 7.6 | na |