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Table 1 Selected clinical, neuropathological and genetic details on patients studied. FTLD = Frontotemporal Lobar degeneration; MND = Motor Neurone Disease

From: Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene

Group M/F Age at onset (y) Age at death (y) Duration of illness (y)
FTLD-TDP type A (n = 25) 14/11 61.0 ± 5.9 69.0 ± 5.1 8.0 ± 3.3
FTLD-TDP type B (n = 15) 9/6 57.1 ± 7.4 62.3 ± 8.0 5.3 ± 4.5
FTLD-TDP type C (n = 10) 6/4 59.9 ± 7.1 71.8 ± 5.7 11.9 ± 5.0
FTLD-tau (n = 11) 4/7 51.4 ± 6.4 61.4 ± 5.4 10.0 ± 3.1
MND (n = 4) 4/0 53.3 ± 7.3 56.3 ± 8.3 3.0 ± 1.4
FTLD/MND C9orf72 expansion (n = 21) 13/8 57.3 ± 6.0 63.5 ± 6.4 6.2 ± 4.1
FTLD GRN mutation (n = 9) 5/4 60.7 ± 5.6 69.3 ± 4.1 8.7 ± 3.9
FTLD No mutation (n = 24) 15/9 60.2 ± 7.8 68.5 ± 8.9 8.4 ± 4.9
FTLD MAPT mutation (n = 11) 4/7 51.4 ± 6.4 61.4 ± 5.4 10.0 ± 3.1
Healthy Controls (n = 10) 3/7 na 83.3 ± 7.6 na