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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma

Fig. 4

H3K27M and H3K27me3 Tissue Immunohistochemical Staining. Immunohistochemical staining for H3K27M and H3K27me3 was evaluated in tumor tissue specimens (n = 7). H3K27M staining patterns were consistent with CSF and tumor tissue sequencing results. Decreased H3K27me3 was observed in H3.3K27M mutant tumor tissue (PID 5), relative to wild type specimens (PID 6, 10, 11). Similar results were observed in PID 8 and 9 (data not shown). Tumor histologic diagnosis was confirmed with Hematoxylin and Eosin staining. Scale bar = 50 microns

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Acta Neuropathologica Communications

ISSN: 2051-5960

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