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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein

Fig. 5

Behavioral Assessment of Mice Following sCHI (or sham). Groups of mice from each of the three mouse strains were subjected to sCHI (or sham) and evaluated for cognitive deficits, as described in Materials and Methods, beginning at 7 days post neurotrauma. learning and memory was assessed were performed on 8 mice per group. The total number of shock zone entrances in four trials (a) measured the ability of the mice to learn the shock zone location. Cognitive deficits are represented by an increase in the shock zone entrances. Significant differences were observed between: WT Sham vs WT sCHI (## p = 0.0052), Tga20 Sham vs Tga20 sCHI (#### p = 0.0001), WT sCHI vs Tga20 sCHI (**** p = 0.0001) as well as Tga20 sCHI vs PrPKO sCHI (‡‡‡‡ p = 0.0001). The total distance traveled in four trials (b) assesses an aversively conditioned ability to inhibit movement. An increase in the total distance traveled suggests cognitive impairment. Significant differences were found between WT Sham vs WT sCHI (# p = 0.0493), Tga20 Sham vs Tga20 sCHI (#### p = 0.0001), WT sCHI vs Tga20 sCHI (**** p = 0.0001), WT sCHI vs PrPKO sCHI (* p = 0.0497) as well as Tga20 sCHI vs PrPKO sCHI (‡‡‡‡ p = 0.0001). The maximum time of avoidance on the 4th trial (c) assayed the ability of the mouse to retain the shock zone location from the previous trial. An increase in the maximum time of avoidance suggests superior learning ability of mice due to training. Significant differences were found between WT Sham vs WT sCHI (#### p = 0.0001), Tga20 Sham vs Tga20 sCHI (### p = 0.001), WT sCHI vs PrPKO sCHI (** p = 0.0063) as well asTga20 sCHI vs PrPKO sCHI (‡‡ p = 0.0047)

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