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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

Fig. 1

Decreased nucleolar volume in neurons from C9FTLD patient brain compared with neurons from neurologically-normal control brain. a Representative images of frontal cortex from neurologically-normal controls and heterozygous (C9 Het) and homozygous (C9 Hom) C9FTLD cases immunostained for the nucleolar protein nucleophosmin (NPM, green), the neuronal marker (NeuN, magenta) with DAPI nuclear stain (blue). Scale bar represents 2 μm. b, c Quantification of neuronal nucleolar volume determined by nucleophosmin immunoreactivity. Frequency distribution of pooled control and C9FTLD (heterozygous cases only) nucleolar volumes show a shift to reduced volumes in C9FTLD cases (b). Median nucleolar volume was significantly decreased in C9FTLD cases compared with controls (c). Each dot represents an individual case with the homozygous C9FTLD case shown in red, and the average and SEM of heterozygous cases shown as long and short horizontal bars, respectively. Significance was determined by unpaired t test: *p < 0.05

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