Fig. 1From: Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathyPharmacokinetics and safety profile of taxifolin. Taxifolin is mostly degraded within an hour, and is rarely detected in the brain parenchyma. Survival rate is not affected by taxifolin treatment. a Line graphs showing changes in blood taxifolin concentration in 8-week-old WT mice receiving 30 mg/kg (filled triangle), 100 mg/kg (filled square), or 300 mg/kg (filled circle) of single taxifolin administration per oral (n = 3 for each). b Line graphs showing blood and brain taxifolin concentration in 9-week-old WT mice fed with the pelleted chow containing 3% taxifolin (n = 3). The first vertical axis represents blood concentration (filled circle). The second axis represents brain concentration (open circle). c A histogram showing brain taxifolin concentration in Tg-SwDI mice with taxifolin treatment at the age of 6 and 14 months (n = 5–6 for each groups). d Kaplan-Meier plots showing taxifolin does not affect survival rate of WT (black line) and Tg-SwDI mice treated with vehicle (red line) or taxifolin (blue line) (n = 28–33 for each group). Error bars indicate ± SEBack to article page