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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

Fig. 1

Pharmacokinetics and safety profile of taxifolin. Taxifolin is mostly degraded within an hour, and is rarely detected in the brain parenchyma. Survival rate is not affected by taxifolin treatment. a Line graphs showing changes in blood taxifolin concentration in 8-week-old WT mice receiving 30 mg/kg (filled triangle), 100 mg/kg (filled square), or 300 mg/kg (filled circle) of single taxifolin administration per oral (n = 3 for each). b Line graphs showing blood and brain taxifolin concentration in 9-week-old WT mice fed with the pelleted chow containing 3% taxifolin (n = 3). The first vertical axis represents blood concentration (filled circle). The second axis represents brain concentration (open circle). c A histogram showing brain taxifolin concentration in Tg-SwDI mice with taxifolin treatment at the age of 6 and 14 months (n = 5–6 for each groups). d Kaplan-Meier plots showing taxifolin does not affect survival rate of WT (black line) and Tg-SwDI mice treated with vehicle (red line) or taxifolin (blue line) (n = 28–33 for each group). Error bars indicate ± SE

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