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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis

Fig. 2

Ca2+ signaling transcriptome perturbations in IBM and related post-hoc analyses. a Heat map of differentially expressed (q < 0.05) genes in IBM (n = 9) versus controls (CON; n = 7) from the KEGG Ca2+ signaling pathway. b Representative network image showing the relationship between Ca2+ signaling and transcriptomic regulators; Ca2+ abundance was considered a significant (q < 0.01) upstream regulator of observed changes. Orange nodes indicate activation consistent with Ca2+ abundance. c Expression of mRNA (FPKM) for the genes encoding previously immunoblotted Ca2+-regulatory proteins, demonstrating no significant (q < 0.05) changes in expression. d Reduced protein to transcript ratio amongst Ca2+-regulatory proteins in IBM, expressed as mean + SEM. *P < 0.05 versus CON

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