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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

Fig. 7

DOPAL-modified α-synuclein (α-syn) levels are unchanged whereas Ser129-phosphorylated α-synuclein (pSer129 α-syn) levels are elevated in G2019K knock-in (KI) mice. Relative quantification and representative blots of DOPAL-bound α-syn pull-down with aminophenylboronic acid (APBA) resin of striata from 12-month-old G2019S KI mice and age-matched WT controls (a). In the same preparation, pSer129 α-syn levels (c) were quantified relatively to α-syn levels (b). Data are expressed as mean ± SEM of n = 11 mice per group. Statistical analysis was performed by the Student t-test, two tailed for unpaired data. **p < 0.01 different from WT

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