Fig. 3

Dopamine (DA) release is preserved in G2019S knock-in (KI) mice. [³H]-DA preloaded synaptosomes obtained from the striata of 12-month-old G2019S KI mice and age-matched WT littermates were continuously superfused with Krebs and stimulated with 3 pulses (90 s) of 10 mM or 20 mM K⁺ (18 min apart). DA release has been expressed as fractional release (FR; i.e. tritium efflux expressed as percentage of the tritium content in the filter at the onset of the corresponding collection period; a), or NET FR (i.e. K⁺-evoked tritium overflow as percent of the tritium content in the filter at the onset of the corresponding collection period; b). Data are means ± SEM of 9 determinations per group