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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

Fig. 3

Dopamine (DA) release is preserved in G2019S knock-in (KI) mice. [3H]-DA preloaded synaptosomes obtained from the striata of 12-month-old G2019S KI mice and age-matched WT littermates were continuously superfused with Krebs and stimulated with 3 pulses (90 s) of 10 mM or 20 mM K+ (18 min apart). DA release has been expressed as fractional release (FR; i.e. tritium efflux expressed as percentage of the tritium content in the filter at the onset of the corresponding collection period; a), or NET FR (i.e. K+-evoked tritium overflow as percent of the tritium content in the filter at the onset of the corresponding collection period; b). Data are means ± SEM of 9 determinations per group

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