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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

Fig. 1

Phosphorylation levels of LRRK2 at Ser1292 (pSer1292) are elevated in G2019S knock-in (KI) mice. Striatal pSer1292 and total LRRK2 levels were measured by Western blotting in 12-month-old G2019S KI mice and age-matched WT controls. Representative blots (left) and quantification (right) are shown. Data are expressed as pSer1292 LRRK2/total LRRK2 and are means ± SEM of 7 animals per group. Statistical analysis was performed with the Student t-test, two tailed for unpaired data. **p < 0.01, different from WT

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