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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease

Fig. 6

Aberrant types of astrocytes in double mutant 1 month old. a Abnormal astrocytes in str. lacunosum-moleculare (str.lac-mol) with irregular shape and abundance of variably shaped and sized RFs. a1 Enlarged boxed area in (a) shows astrocyte with a lobulated nucleus (An animation of Z-stack of optical slices in image (a1)’ see in Additional file 7: Movie 2) and many polymorphic Rosenthal fibers (in black and white in (a1)’). b Abnormal astrocytes in the subpial area. b1 Enlarged boxed area in (b) shows an astrocyte with a lobulated nucleus and many RFs. An animation of Z-stack of optical slices in image (b1)’ is shown in Additional file 8: Movie 3. c Ultrastructure of an astrocyte in the str. lacunosum-moleculare (str.lac-mol) with a lobulated nucleus (N) and RFs. (c1) Enlarged boxed area in (c). Note RF with surrounding intermediate filaments near a protrusion of the nucleus. c2) Enlarged boxed area in (c1). Note that intermediate filaments are in close apposition to nuclear pores (arrows). a and b –confocal images from slices stained for GFAP and counterstained with DAPI. Black and white images show DAPI staining. Scale bars: 55 μm in (a), 85 μm in (b), and 2 μm in (c)

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