Fig. 2
From: The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease
Small RFs in AxD mice. a RFs in the cell body of astrocyte near blood vessel (V). double mutant 1 week-old mouse. a1 enlarged boxed area in (a). Note a small osmiophilic protrusion (arrow) from Rosenthal fiber (RF) composed of granular material and profiles of filaments. Granular material, similar in size to those in the inclusions, are attached to filaments or from small groupings (arrowheads). b A group of small, electron dense bodies connected by filaments in TG 1 year-old mouse. Arrowheads indicate small aggregates on filaments. c Astrocyte process with RFs (arrows) of different sizes. KI homozygous 1 year-old mouse. c1 enlarged boxed area in (c). Note that two small osmiophilic profiles are ‘connected’ to large Rosenthal fiber (RF) by granular, electron dense material located on filaments. The electron dense material of small profiles has a granular pattern and includes filaments. Electron dense granules (arrowheads) similar in size to those in the aggregates are located on filaments around the RF. N –nucleus of the astrocyte. Scale bars: 6 μm in (a) and (c); 250 nm in (b)