Fig. 1
From: The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease
Variability in the ultrastructure of Rosenthal fibers (RFs) in AxD mice. a RFs with oval shape (arrows, only some marked) in the astrocyte body and proximal part of the process. TG 1 year-old mouse. b Elongated RFs (arrow) in the astrocyte endfoot near blood vessel (V), note that in neighboring astrocyte process RFs have oval shape (arrowheads). TG 1 month-old mouse. c Different morphologies of RFs in neighboring astrocytes near blood vessel (V). Note that in lower left group of RFs (arrow) dark central material is encircled by small undulating, ramified bands of RFs, whereas in other cell oval shape RFs form compact group (arrowhead). KI homozygous 1 year-old mouse. d, e Focal (d) and dispersed (e) localizations of RFs in the cytoplasm. Note that in (d) the area with RFs and surrounding filaments (arrow) is sharply demarcated from cytoplasm whereas in (e) RFs (arrows) are distributed within cytoplasm and intermingled with organelles. d KI homozygous 1 year-old mouse. e double mutant 1 month-old mice. N- astrocyte nucleus. Scale bars: 7 μm in (a)-(d); 4 μm in (e)