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Table 1 Summary of Significant Modules

From: Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice

Label Num. of genes Color Eigengene (ME) in response to NSC Associated phenotypes Top hub gene Gene name Additional hub genes Annotation
M1 1848 turquoise up pSer31TH, GLT1, mBDNF, NP, NO Nat9 N-Acetyltransferase 9 (GCN5-Related, Putative) Zfand6, C4b, Mtg2, H2-K1, Eif2ak2, Mcmbp, Herc6, Nqo1 GABAergic spiny neurons, immunity, oligodenrocyte, synapsis
M2 1499 blue down pSer31TH, GLT1, mBDNF, NP, NO Ly6k Lymphocyte Antigen 6 Complex, Locus K Lrrc17, Spinkl, Tes, Ltbp4, Krtap13-1, Srsx, Muc6, Cpvl cortical neurons glutamate tramsmission,
immunity
M3 589 brown down pSer31TH, NP, NO Elavl4 ELAV Like Neuron-Specific RNA Binding Protein 4 Nmnat2Sphkap, Fads3, Limk1, Magee1, Dner, acetylcholinergic interneurons, synapsis
M4 300 yellow up pSer31TH Itpr1 Inositol 1,4,5-Trisphosphate Receptor, Type 1 Pcdhb14, Actn2, Cacna2d3, Adcy5, Grin3 Ca regulation, synapsis
M10 65 purple down GLT1, Rotarod Dnajc30 DnaJ (Hsp40) Homolog, Subfamily C, Bloc1s1, Spg21, Tpgs1, Mtx1, Alkbh7, mitochondria, lysosome, immunity,
M11 63 greenyellow down pSer31TH, NO Olfr714 olfactory receptor 714 Kfl11, Cd101 immunity,
M13 50 salmon up NO Cdhr3 cadherin-related family member 3 Spef2, Foxj1, Eno4 migration
M15 45 midnightblue down Rotarod Cp curoplasmin Omd, Fn1, Lilrb4a cell adhesion, immunity
M16 42 lightcyan down pSer31TH, NO Olfr8 olfactory receptor 8 Slc17a3, Olfr429 immunity
M17 41 grey60 down pSer31TH, GLT1, NO, Rotarod, BT Snord99 small nucleolar RNA, C/D box 99 Ep400, Rpl5, Snora7a, Tmem141 mitochondria, immunity,
M18 39 lightgreen up Rotarod, BT Krt25 keratin 25 Tmtc2 mitosis
  1. NO Novel Object, NP Novel Place, BT Beam Transversal