Table 1 Summary of Significant Modules
Label | Num. of genes | Color | Eigengene (ME) in response to NSC | Associated phenotypes | Top hub gene | Gene name | Additional hub genes | Annotation |
|---|---|---|---|---|---|---|---|---|
M1 | 1848 | turquoise | up | pSer31TH, GLT1, mBDNF, NP, NO | Nat9 | N-Acetyltransferase 9 (GCN5-Related, Putative) | Zfand6, C4b, Mtg2, H2-K1, Eif2ak2, Mcmbp, Herc6, Nqo1 | GABAergic spiny neurons, immunity, oligodenrocyte, synapsis |
M2 | 1499 | blue | down | pSer31TH, GLT1, mBDNF, NP, NO | Ly6k | Lymphocyte Antigen 6 Complex, Locus K | Lrrc17, Spinkl, Tes, Ltbp4, Krtap13-1, Srsx, Muc6, Cpvl | cortical neurons glutamate tramsmission, immunity |
M3 | 589 | brown | down | pSer31TH, NP, NO | Elavl4 | ELAV Like Neuron-Specific RNA Binding Protein 4 | Nmnat2Sphkap, Fads3, Limk1, Magee1, Dner, | acetylcholinergic interneurons, synapsis |
M4 | 300 | yellow | up | pSer31TH | Itpr1 | Inositol 1,4,5-Trisphosphate Receptor, Type 1 | Pcdhb14, Actn2, Cacna2d3, Adcy5, Grin3 | Ca regulation, synapsis |
M10 | 65 | purple | down | GLT1, Rotarod | Dnajc30 | DnaJ (Hsp40) Homolog, Subfamily C, | Bloc1s1, Spg21, Tpgs1, Mtx1, Alkbh7, | mitochondria, lysosome, immunity, |
M11 | 63 | greenyellow | down | pSer31TH, NO | Olfr714 | olfactory receptor 714 | Kfl11, Cd101 | immunity, |
M13 | 50 | salmon | up | NO | Cdhr3 | cadherin-related family member 3 | Spef2, Foxj1, Eno4 | migration |
M15 | 45 | midnightblue | down | Rotarod | Cp | curoplasmin | Omd, Fn1, Lilrb4a | cell adhesion, immunity |
M16 | 42 | lightcyan | down | pSer31TH, NO | Olfr8 | olfactory receptor 8 | Slc17a3, Olfr429 | immunity |
M17 | 41 | grey60 | down | pSer31TH, GLT1, NO, Rotarod, BT | Snord99 | small nucleolar RNA, C/D box 99 | Ep400, Rpl5, Snora7a, Tmem141 | mitochondria, immunity, |
M18 | 39 | lightgreen | up | Rotarod, BT | Krt25 | keratin 25 | Tmtc2 | mitosis |