Fig. 7
From: A novel form of necrosis, TRIAD, occurs in human Huntington’s disease
Signaling pathway and conditions for TRIAD are consistent for the observation in human HD neurons. The second panel from the left shows signaling pathway and condition necessary for TRIAD. Our observation in human HD brains supports these conditions are satisfied in cortical neurons of human HD. In addition, our analyses indicated the morphological changes consistent with TRIAD. Plk1 activation shifts the partner transcription factor of YAP/YAPdeltaC from TEAD to p73, thereby shifting the signal from survival to apoptosis [8]. The loss of YAP/YAPdeltaC-TEAD survival signal leads to TRIAD type of necrosis [8]. Asterisk indicates the condition confirmed in human HD neurons by this study