Fig. 3

LATS1 is activated in cortical neurons of postmortem human HD patients. a Co-staining of phosphorylated LATS1 and MAP2 with cerebral cortex (frontal cortex) of HD patients (grade IV) and non-neurological disease control. At low magnification, signal intensities were high in HD but low in the control (upper panel, lower graph). High magnification revealed that the signals were localized to MAP2-positive neurons (lower panels). The lower graph shows mean + SEM of the pLATS1 signal intensity per neuron of three patients or three controls (for N = 1, mean value of signal intensities of 100 neurons from 4 visual fields were used). Non-neurological disease patients were used as control. **: p < 0.01 in Student’s t-test. b Co-staining of phosphorylated PLK1 and NeuN with cerebral cortex (frontal cortex) of HD patients (grade IV) and non-neurological disease control. At low magnification, signal intensities were high both in HD and control (upper panel, lower graph). High magnification revealed that the signals were localized to NeuN-positive neurons (lower panels). The lower graph shows mean + SEM of the PLK1 signal intensity per neuron of three patients or three controls (for N = 1, mean value of signal intensities of 100 neurons from 4 visual fields were used). Non-neurological disease patients were used as control. **: p < 0.01 in Student’s t-test