Fig. 1
From: A novel form of necrosis, TRIAD, occurs in human Huntington’s disease
LATS1 and PLK1 are activated in Htt-KI mice. a Chronological analyses of LATS1, PLK1 and their phosphorylated forms by western blot with cerebral tissues including striatum from Htt-KI and their background mice (WT). The right graphs show the ratios of pLATS1/LATS1 and pPLK1/PLK1 in western blot analyses that are corrected by the value of WT at 12 weeks. b Immunostaining of striatal tissues from mutant Htt-KI (111Q) and their background mice with anti-phospho-LATS1 and anti-phospho-PLK1 antibodies. The lower graphs show relative intensities of immunostains in squared areas after subtraction with background stain signals. Mean value of signal intensity/area from twenty visual fields was used for N = 1. The bar graphs show mean + SEM. *: p < 0.05 in Student’s t-test