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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

Fig. 5

AAV1/2-A53T-aSyn SN develop insoluble pSer129 aSyn with Lewy-like pathology. There was no positive immunostaining for pSer129 aSyn in human control nigra (a). In contrast, in animals injected with AAV1/2-A53T-aSyn there was a strong signal for pSer129 aSyn in the SN of the ipsilateral hemisphere including several densely labelled cells (b). Human PD nigral Lewy bodies stained with the same method are provided for comparison (c). Similarly, several structures were noted in mouse brain (d) with morphology consistent with Lewy neurites in human PD brain (e)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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