Skip to main content
Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

Fig. 4

AAV1/2-A53T-aSyn SN develop insoluble aSyn + aggregates with Lewy-like pathology. a-g Immunhistochemical staining for aSyn with Lewy body specific LB509 antibody after proteinase K digestion. While AAV1/2-EV control (a) and human control SN (b) do not show any positive aSyn labelling, AAV1/2-A53T-aSyn injected mice maintain a widespread aSyn positivity after proteinase K digestion (c) that is located in perikarya (d) and in neurites (f). From a morphological perspective, these findings resemble the situation found in human PD sections corresponding to a Lewy-like pathology (e, g)

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us