Fig. 4
From: High plasticity of axonal pathology in Alzheimer’s disease mouse models
Re-formation of AxDs. Dendrites and axons expressing GFP (green) in contact with Aβ plaques stained with Methoxy-XO4 (blue) in the supragranular layers of the somatosensory cortex of the dE9 mouse (two-photon microscopy). (a-d), Maximum projection of images taken around an Aβ plaque (40 images, z = 1 μm) at different time points. The AxD (dys 4; arrow) is smaller on day 10 (b), and has disappeared on day 126 (d). Notice that the parental axon on day 126 is shortened. (e-g), Maximum projection of images taken around another Aβ plaque (40 images, z = 1 μm) at different time points. The AxD (dys 3; arrow) disappeared on day 10 (f) but the parental axon remains. A new large AxD is generated at the same point on day 133. The days shown refer to the number of days after day 0 (when imaging began). Scale bar (in g): 25.9 μm in a-d and 19.5 in e-g