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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: High plasticity of axonal pathology in Alzheimer’s disease mouse models

Fig. 3

Volume and morphological changes of in vivo AxDs over time. (a, b), Graphs showing the changes in volume of the different AxDs studied over time in the dE9 (a) and the APP-PS1 (b) mice. (c, d), Size ratio indicates the ratio between the volume of an AxD and the volume of its equivalent non-dystrophic axonal segment. Graphs correspond to the same AxDs represented in a, b, respectively. With the aim of simplifying the graph visualization, the AxD size ratio was plotted only from the imaging day in which the AxD became dystrophic (size ratio ≥2, dashed line). Note that in a-d the scale has been transformed to Log 10 to illustrate that volume values of larger and smaller AxDs can be very similar at some time points. The days shown refer to the number of days after day 0 (when imaging began). Graph legend: Asterisks refer to those AxDs that disappear at the end of the imaging period (one asterisk means the parental axon stays and two asterisks mean that the AxD disappears due to the loss of the parental axon); underlined AxDs (dys) are those that show morphology changes (more than one swollen varicosity of irregular shape and new short axonal segments). (e), Correlation between the mean sphericity value over time and the maximum volume that the AxD reaches. Larger AxDs tend to be more complex, non-spherical shapes (Pearson’s r: −0.7366, p < 0.0001). (f), Correlation between the AxD lifetime and the maximum AxD volume in the APP-PS1 mouse. Larger AxDs tend to have longer lifetimes (Pearson’s r: 0.4974, p = 0.0071). (g), Comparison between the axon type (EPB en passant bouton axons, TB terminal bouton axons) and the maximum volume that the AxD reaches in the APP-PS1 mouse. The size of AxDs is not related to the type of axon in which they are formed (Mann–Whitney U: 163.0; p = 0.6339)

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