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Table 1 Clinical, demographic, and neuropathological characteristics by diagnosis category

From: Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

  Clinical Diagnosis   
NCI
(N = 11)
aMCI
(N = 10)
AD
(N = 8)
P-value Pair-wise comparison
Age (years) at death:
 Mean ± SD 82.3 ± 2.9 85.4 ± 7.2 84.8 ± 2.6 0.3a --
 (Range) (77–86) (74–96) (80–88)   
Number (%) of males: 6 (54%) 4 (40%) 4 (50%) 0.5b --
Years of education:
 Mean ± SD 19.1 ± 2.1 17.9 ± 5.2 19.0 ± 2.7 0.9a --
 (Range) (15–22) (8–23) (14–22)   
Number (%) with ApoE ε4 allele: 3 (27%) 2 (20%) 3 (38%) 0.2b --
MMSE:
 Mean ± SD 27.9 ± 1.5 26.3 ± 2.3 20.0 ± 4.9 0.0008a NCI > AD
 (Range) (26–30) (22–30) (14–27)   
Global Cognitive Score:
 Mean ± SD 0.59 ± 0.3 0.02 ± 0.3 −1.0 ± 0.6 0.0002a NCI > (MCI, AD)
 (Range) (−0.08–0.9) (−0.53–0.3) (−1.5– −0.2)   
Post-mortem interval (hours):
 Mean ± SD 4.9 ± 2.0 6.2 ± 5.2 4.0 ± 1.1 0.8a --
 (Range) (2.2–8.5) (2.0–15.0) (2.7–5.8)   
Distribution of Braak scores:
 0 0 0 0   
 I/II 4 1 0 0.02a NCI < AD
 III/IV 6 7 3   
 V/VI 1 2 5   
NIA Reagan diagnosis (likelihood of AD):
 No AD 0 0 0   
 Low 5 4 0 0.03a (NCI, MCI) < AD
 Intermediate 5 4 4   
 High 1 2 4   
CERAD diagnosis:
 No AD 3 4 0   
 Possible 2 2 0 0.02a (NCI, MCI) < AD
 Probable 4 2 3   
 Definite 2 2 5   
  1. aKruskal-Wallis test, with Bonferroni correction for multiple comparisons. bFisher’s exact test, with Bonferroni correction for multiple comparisons