Fig. 4
From: Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease
Alterations in select transcripts isolated from noradrenergic LC neurons correlate with global cognition during the progression of AD. Scatterplots show significant relationships between decreasing levels of a Cytc1 (r = 0.64, p < 0.0001), b Nrf1 (r = 0.57, p = 0.0003), c Map1b (r = 0.59, p = 0.0006), and d Synpo (r = 0.65, p < 0.0001) and worsening GCS score, via Spearman rank correlation analysis. Symbols: NCI (blue-filled circle), aMCI (green-filled circle), AD (red-filled circle)