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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

Fig. 8

Confocal analysis of phosphorylated neurofilaments in 1H7 passively immunized mice. α-Syn KO, non-tg, and α-syn tg mice were passively immunized weekly for 13 weeks with either 27-1 (control) or 1H7 (α-syn antibody) beginning one week after LV-α-syn unilateral injection. Pathological analysis of axonal density using SMI312 antibody against phosphorylated neurofilaments was conducted 16 weeks following unilateral LV-α-syn injection. a Representative images and (b) computer-aided analysis of axonal density in the contra- and ipsilateral side of α-syn KO mice. c Representative images and (d) computer-aided analysis of axonal density in the contra- and ipsilateral side of non-tg mice. e Representative images and (f) computer-aided analysis of axonal density in the contra- and ipsilateral side of α-syn tg mice. *P-value < 0.05 using ANOVA followed by Dunnett’s post-hoc test comparing 27-1 (control) and 1H7 (antibody) within a hemisphere. # P < 0.05 using ANOVA followed by Tukey-Kramer post hoc test comparing contra- and ipsilateral sides. Scale bar = 30 μm

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