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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

Fig. 7

Effects of passive immunization on axonal accumulation of α-syn in ipsi- and contralateral sides. α-Syn KO, non-tg, and α-syn tg mice were passively immunized (intraperitoneal injections) weekly for 13 weeks with either 27-1 (control) or 1H7 (α-syn antibody) beginning one week after LV-α-syn unilateral injection. Pathological analysis was conducted 16 weeks following unilateral LV-α-syn injection. Representative photomicrographs of total α-syn accumulation in hippocampal axons in (a) α-syn KO, (b) non-tg, and (c) α-syn tg mice. Arrows indicate dystrophic neurites. Scale bar = 25 μm

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